1 Wang W, Xiang LY, Ma YC, Chen JW, Peng L, Gao XS, Zhang FX, Xiong Y, Qin F, Yuan JH. The association between heavy metal exposure and erectile dysfunction in the United States. Asian J Androl. 2023 Mar-Apr;25(2):271-276. doi: 10.4103/aja202237. PMID: 35708358; PMCID: PMC10069686:
2 Anis TH, ElKaraksy A, Mostafa T, Gadalla A, Imam H, Hamdy L, Abu el-Alla O. Chronic lead exposure may be associated with erectile dysfunction. J Sex Med. 2007 Sep;4(5):1428-34; discussion 1434-6. doi: 10.1111/j.1743-6109.2007.00587.x. Erratum in: J Sex Med. 2008 Jan;5(1):252. PMID: 17727353:
3 https://interplexus.com/blogs/news/effects -of-toxic-heavy-metals-on-men-s-health-testosterone-levels# :~:text=Research%20shows%20exposure %20to%20arsenic,potentially% 20reduce%20your%20testosterone%20levels
4 Scutarașu EC, Trincă LC. Heavy Metals in Foods and Beverages: Global Situation, Health Risks and Reduction Methods. Foods. 2023 Sep 6;12(18):3340. doi: 10.3390/foods12183340. PMID: 37761050; PMCID: PMC10528236
5 https://www.health.harvard. edu/heart-health/heavy- metals-found-in- popular-brands-of- dark-chocolate
6 https://indexmedicus.afro.who .int/iah/fulltext/ M%C3%A9taux%20lourds %20plus%20polluant% 20malnutrition%20enfant.pdf
7 https://iris.who.int /handle/10665/107872
8 http://www.health.harvard.edu www.health.harvard.edu/heart- health/low-level-exposure -to-toxic-metals-a-risk-for -clogged-arteries
9 Teitelbaum, J.; Goudie, S. An Open-Label, Pilot Trial of HRG80™ Red Ginseng in Chronic Fatigue Syndrome, Fibromyalgia, and Post-Viral Fatigue. Pharmaceuticals 2022, 15, 43.
10 https://www.healthline.com /nutrition/saffron
11 https://www.rxlist.com/supplements/saffron .htm#:~:text=Men%20use%20it%20to%2 0prevent,scalp%20for %20baldness%20(alopecia)
12 Dissanayake D, Wijesinghe PS, Ratnasooriya WD, Wimalasena S. Effects of zinc supplementation on sexual behavior of male rats. J Hum Reprod Sci. 2009 Jul;2(2):57-61. doi: 10.4103/0974-1208.57223. PMID: 19881149; PMCID: PMC2800928
13 https://www.tf1info.fr/france/ contamination-aux-metaux -lourds-des-habitants -du-gard-portent-plainte-1250256.html
14 https://www.france.tv/ france-5/le-monde-en-face /31679-pollution-des-sols -le-scandale-cache-aluminium-notre -poison-quotidien.html
15 https://www.bfmtv.com /sante/arsenic-cuivre-tous- les-francais-sont- contamines-aux- metaux-lourds-y-compris-les-enfants_ AN-202107050480.html
16 https://www.lemonde.fr/planete /article/2021/07/05/arsenic-cadmium -chrome-tous-les-francais-sont-contamines-aux-metaux -lourds-y-compris-les- enfants_6087007_3244.html
17 https://www.lefigaro.fr/sciences /mercure-arsenic-cuivre- tous-les-francais-meme- les-enfants-sont-exposes-aux- metaux-lourds-20210706
18 https://www.canr.msu. edu/news/heavy-metals-in-food# :~:text=Often%2C %20heavy%20metals%20are% 20found,copper% 20(1%2C2)
19 https://www.sciencedirect.com/ science/article/pii/ S1018364722000465
20 https://www.researchgate.net/ publication/337121874/figure/fig2/ AS:823133267308544@1573261672245 /ncrease-in-heavy-metal-pollution- as-cement-production-increased-3.png
21 https://www.hopkinsmedicine.org /health/conditions- and-diseases/erectile-dysfunction#:~:text= It%20was%20estimated%20that%2C%20in ,be%20approximately %20322%20million%20worldwide
22 https://www.nature.com/articles/s41443-019-0161-8
23 https://www.researchgate.net/ profile/Pierre-Dechelotte/publication/331808337/figure/f ig9/AS:11431281108266426@1671442750623 /Evolution-of-the-point-prevalence-of- different-types-of-EDs-over-the-1982-2002-period.jpg
24 https://lh3.googleusercontent.com /8jQZYlc0uLzkDS_60rmLhhOjGPtLvTXVvg8bKPk2H1 BhomkuhQwGsu8Hw_cF_U6nVGeNs8kg6s8 brrvM8FqJKKsk35ZzeaSMwvPyO ZpR5kPEK0VNJ3mn5-gtlAB9gg_lmoF7elMK
25 Wang W, Xiang LY, Ma YC, Chen JW, Peng L, Gao XS, Zhang FX, Xiong Y, Qin F, Yuan JH. The association between heavy metal exposure and erectile dysfunction in the United States. Asian J Androl. 2023 Mar-Apr;25(2):271-276. doi: 10.4103/aja202237. PMID: 35708358; PMCID: PMC10069686
26 https://onlinelibrary.wiley.com/ doi/full/10.2164/jandrol.107.004200#:~:text =The%20analysis%20supported% 20lead%20toxicity,related% 20to%20oxidative%20stress%20mechanisms
27 Anis TH, ElKaraksy A, Mostafa T, Gadalla A, Imam H, Hamdy L, Abu el-Alla O. Chronic lead exposure may be associated with erectile dysfunction. J Sex Med. 2007 Sep;4(5):1428-34; discussion 1434-6. doi: 10.1111/j.1743-6109.2007.00587.x. Erratum in: J Sex Med. 2008 Jan;5(1):252. PMID: 17727353:
28 Mariana Machado-Neves, Effect of heavy metals on epididymal morphology and function: An integrative review, Chemosphere, Volume 291, Part 2, 2022, https://doi.org/10.1016/j.chemosphere.2021.133020.
29 Ullah, S.; Ennab, W.; Wei, Q.; Wang, C.; Quddus, A.; Mustafa, S.; Hadi, T.; Mao, D.; Shi, F. Impact of Cadmium and Lead Exposure on Camel Testicular Function: Environmental Contamination and Reproductive Health. Animals 2023, 13, 2302.
30 https://austinurologyinstitute.com/blog/ ed-diagnoses-increasing/#:~:text=Medical% 20conditions%20that%20cause% 20or,available%20right%20at%20our%20fingertips
31 https://www.sciencedaily.com/releases/ 2021/12/211209082606.htm
32 https://www.ahajournals.org/doi/ 10.1161/CIRCRESAHA.123.323617
33 https://interplexus.com/blogs/news /effects-of-toxic-heavy-metals-on-men-s-health-testosterone -levels#:~:text=Research%20shows%20exposure %20to%20arsenic,potentially%20reduce %20your%20testosterone%20levels
34 https://jardinage.pagesjaunes.fr /plante/voir/1529/pin-maritime
35 https://www.jardinsdefrance.org /la-foret-des-landes-de-gascogne -royaume-du-pin-maritime/
36 https://www.sciencedirect.com/topics /pharmacology-toxicology-and-pharmaceutical- science/pycnogenol#:~:text=Pycnogenol%2 C%20which%20is%20extracted%20from,and%20 procyanidins%20(or%20proanthocyanidins)
37 Inés Mármol, Javier Quero, Nerea Jiménez-Moreno, M. Jesús Rodríguez-Yoldi, Carmen Ancín-Azpilicueta, A systematic review of the potential uses of pine bark in food industry and health care, Trends in Food Science & Technology, Volume 88, 2019
38 Vazquez, G., Gonzales, J., Freire, S., Lopez-Lorenzo, M., & Antorrena, G. (2002). Removal of cadmium and mercury ions from aqueous solution by sorption on treated Pinus pinaster bark: kinetics and isotherms. Bioresource technology, 82, 247-251
39 https://www.healthline.com/health/heavy-metal-detox
40 Adhikari A, Darbar S, Chatterjee T, Das M, Polley N, Bhattacharyya M, Bhattacharya S, Pal D, Pal SK. Spectroscopic Studies on Dual Role of Natural Flavonoids in Detoxification of Lead Poisoning: Bench-to-Bedside Preclinical Trial. ACS Omega. 2018 Nov 30;3(11):15975-15987. doi: 10.1021/acsomega.8b02046. Epub 2018 Nov 27. PMID: 30556021; PMCID: PMC6288805
41 Lakey-Beitia J, Burillo AM, La Penna G, Hegde ML, Rao KS. Polyphenols as Potential Metal Chelation Compounds Against Alzheimer’s Disease. J Alzheimers Dis. 2021;82(s1):S335-S357. doi: 10.3233/JAD-200185. PMID: 32568200; PMCID: PMC7809605
42 Ceramella, Jessica, Azzurra Chiara De Maio, Giovanna Basile, Anastasia Facente, Elisabetta Scali, Inmaculada Andreu, Maria Stefania Sinicropi, Domenico Iacopetta, and Alessia Catalano. 2024. “Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals” Foods 13, no. 7: 978.
43 Nie F, Liu L, Cui J, Zhao Y, Zhang D, Zhou D, Wu J, Li B, Wang T, Li M, Yan M. Oligomeric Proanthocyanidins: An Updated Review of Their Natural Sources, Synthesis, and Potentials. Antioxidants (Basel). 2023 Apr 26;12(5):1004. doi: 10.3390/antiox12051004. PMID: 37237870; PMCID: PMC10215713
44 Vazquez, G., Gonzales, J., Freire, S., Lopez-Lorenzo, M., & Antorrena, G. (2002). Removal of cadmium and mercury ions from aqueous solution by sorption on treated Pinus pinaster bark: kinetics and isotherms. Bioresource technology, 82, 247-251
45 https://iconline.ipleiria.pt/bitstream/ 10400.8/3233/1/Polyphenols%20for%20an%20increased% 20ability%20to%20cope%20with%20Environmental %20toxicants.pdf
46 https://www.taylorfrancis.com/chapters /edit/10.1201/9781003055419-8/role- dietary-phytochemicals-amelioration- arsenic-induced-cancer-emerging- elixir-nilanjan-das-manisha-guha-xavier-savarimuthu
47 Tian Y, Zhou Q, Li W, Liu M, Li Q, Chen Q. Efficacy of L-arginine and Pycnogenol ® in the treatment of male erectile dysfunction: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2023 Oct 4;14:1211720. doi: 10.3389/fendo.2023.1211720. PMID: 37908749; PMCID: PMC10614297
48 https://www.eurekalert.org /news-releases/837220
49 Stanislavov R, Nikolova V, Rohdewald P. Improvement of erectile function with Prelox: a randomized, double-blind, placebo-controlled, crossover trial. Int J Impot Res. 2008 Mar-Apr;20(2):173-80. doi: 10.1038/sj.ijir.3901597. Epub 2007 Aug 16. PMID: 17703218
50 Stanislavov R, Nikolova V. Treatment of erectile dysfunction with pycnogenol and L-arginine. J Sex Marital Ther. 2003 May-Jun;29(3):207-13. doi: 10.1080/00926230390155104. PMID: 12851125
51 Stanislavov R, Nikolova V. Treatment of erectile dysfunction with pycnogenol and L-arginine. J Sex Marital Ther. 2003 May-Jun;29(3):207-13. doi: 10.1080/00926230390155104. PMID: 12851125
52 https://us.typology.com/l ibrary/what-are-the- active-ingredients-of-ginseng
53 Gillis CN. Panax ginseng pharmacology: a nitric oxide link? Biochem Pharmacol. 1997 Jul 1;54(1):1-8. doi: 10.1016/s0006-2952(97)00193-7. PMID: 9296344.
54 Maria Assunta Potenza, Monica Montagnani, Luigi Santacroce, Ioannis Alexandros Charitos, Lucrezia Bottalico, Ancient herbal therapy: A brief history of Panax ginseng, Journal of Ginseng Research, Volume 47, Issue 3, 2023, Pages 359-365
55 https://zellerag.ch/fr/phytotherapie/ lexique-des-plantes- medicinales/ginseng/
56 https://zellerag.ch/fr/phytotherapie/ lexique-des-plantes-medicinales/ginseng/
57 https://quod.lib.umich.edu/ d/did/did2222.0004.174/— ginseng?rgn=main;view= fulltext;q1=Exotic+botany
58 https://www.moustique.be/actu/2 015/06/30/les-plaisirs-du-roi-soleil-157159
59 https ://absolute-health.org /en/blog/post/article-healthtips-4.html# :~ :text=The%20heavy %20metal%20substance%20also, other%20organs%20of%20the%20body
60 https://www.healthline.com/ nutrition/how-to-increase-nitric-oxide
61 Davies KP. Development and therapeutic applications of nitric oxide releasing materials to treat erectile dysfunction. Future Sci OA. 2015 Aug;1(1):FSO53. doi: 10.4155/fso.15.53. PMID: 27019746; PMCID: PMC4806684
62 Friedl R, Moeslinger T, Kopp B, Spieckermann PG. Stimulation of nitric oxide synthesis by the aqueous extract of Panax ginseng root in RAW 264.7 cells. Br J Pharmacol. 2001 Dec;134(8):1663-70. doi: 10.1038/sj.bjp.0704425. PMID: 11739242; PMCID: PMC1572905
63 Kun Han, Im-Chul Shin, Kang-Ju Choi, Yeo-Pyo Yun, Jin-Tae Hong, Ki-Wan Oh, Korea red ginseng water extract increases nitric oxide concentrations in exhaled breath, Nitric Oxide, Volume 12, Issue 3, 2005, Pages 159-162, ISSN 1089-8603, https://doi.org/10.1016/j.niox.2005.02.001.
64 Lee HW, Lee MS, Kim TH, Alraek T, Zaslawski C, Kim JW, Moon DG. Ginseng for Erectile Dysfunction: A Cochrane Systematic Review. World J Mens Health. 2022 Apr;40(2):264-269. doi: 10.5534/wjmh.210071. Epub 2021 Jun 15. PMID: 34169686; PMCID: PMC8987140
65 https://www.safran-occitanie.com/blogs/ culture-du-safran/le-prix-du-safran?srsltid=Afm BOoo8inzGZymnIus9Kb_ Heetp6uAReVPIUi142KMUVQaNLEH2yrIa
66 https://www.safran-occitanie.com/blogs/ culture-du-safran/le-prix-du-safran?srsltid =AfmBOoo8inzGZymnIus9Kb_ Heetp6uAReVPIUi142KMUVQaNLEH2yrIa
67 https://www.healthline.com/nutrition/ saffron#aphrodisiac
68 El Midaoui A, Ghzaiel I, Vervandier-Fasseur D, Ksila M, Zarrouk A, Nury T, Khallouki F, El Hessni A, Ibrahimi SO, Latruffe N, Couture R, Kharoubi O, Brahmi F, Hammami S, Masmoudi-Kouki O, Hammami M, Ghrairi T, Vejux A, Lizard G. Saffron (Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases. Nutrients. 2022 Jan 29;14(3):597. doi: 10.3390/nu14030597. PMID: 35276955; PMCID: PMC8839854
69 https://www.thestar.com/life/health-wellness/ add-saffron-ginseng-to-your-diet-to-spice-up-your-sex -life-study/article_7dc6bfcf-8d23-57a7- a09e-073fb698467e.html
70 Modabbernia A, Sohrabi H, Nasehi AA, Raisi F, Saroukhani S, Jamshidi A, Tabrizi M, Ashrafi M, Akhondzadeh S. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology (Berl). 2012 Oct;223(4):381-8. doi: 10.1007/s00213-012-2729-6. Epub 2012 May 3. PMID: 22552758
71 Shamsa A, Hosseinzadeh H, Molaei M, Shakeri MT, Rajabi O. Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study. Phytomedicine. 2009 Aug;16(8):690-3. doi: 10.1016/j.phymed.2009.03.008. Epub 2009 May 9. PMID: 19427775
72 https://nutritionsource.hsph.harvard.edu/zinc/# :~:text=Zinc%20is%20a%20trace %20mineral,supporting %20a%20healthy% 20immune%20system.
73 Prasad AS, Mantzoros CS, Beck FW, Hess JW, Brewer GJ. Zinc status and serum testosterone levels of healthy adults. Nutrition. 1996 May;12(5):344-8. doi: 10.1016/s0899-9007(96)80058-x. PMID: 8875519
74 https://www.healthline.com/health/ benefits-testosterone
75 Dissanayake D, Wijesinghe PS, Ratnasooriya WD, Wimalasena S. Effects of zinc supplementation on sexual behavior of male rats. J Hum Reprod Sci. 2009 Jul;2(2):57-61. doi: 10.4103/0974-1208.57223. PMID: 19881149; PMCID: PMC2800928
76 Prasad AS, Mantzoros CS, Beck FW, Hess JW, Brewer GJ. Zinc status and serum testosterone levels of healthy adults. Nutrition. 1996 May;12(5):344-8. doi: 10.1016/s0899-9007(96)80058-x. PMID: 8875519
77 https://mensfitnessonline.com.au/ive-made -more-than-3000-pornos-heres-what- i-eat-and-what-to-eat-for-better-sex/
78 https://food.ec.europa.eu/system/files/2019-03/ cs_contaminants_catalogue_cadmium_chocolate_en.pdf
79 https://www.health.harvard.edu/heart-health/heavy -metals-found-in-popular-brands-of-dark-chocolate
80 https://pubs.rsc.org/en/content/ articlelanding/2018/ em/c8em00069g
81 Mohammad Hassan Emami, Farideh Saberi, Safoora Mohammadzadeh, Alireza Fahim, Mohammad Abdolvand, Sayed Ali Ehsan Dehkordi, Samane Mohammadzadeh, Fatemeh Maghool, A Review of Heavy Metals Accumulation in Red Meat and Meat Products in the Middle East, Journal of Food Protection, Volume 86, Issue 3, 2023, https://doi.org/10.1016/j.jfp.2023.100048.)
82 Su LJ, Chiang TC, O’Connor SN. Arsenic in brown rice: do the benefits outweigh the risks? Front Nutr. 2023 Jul 14;10:1209574. doi: 10.3389/fnut.2023.1209574. PMID: 37521417; PMCID: PMC10375490